Learning Objectives: 1) Review the nature of the increasing problem of interpreting very large data sets. 2) Describe some of the tools currently available to assist in very large data set interpretation. 3) Describe the SCAR TRIP initiative-new technologies for dealing with these very large data sets. Disclosure: (S.C.H. receives royalties as a book editor for Spie and is an Advisory Board Member for Stentor, Inc.)