Learning Objectives: This course will enable the attendee to: 1) Identify the indications for percutaneous needle biopsy under stereotactic, sonographic, and MR imaging guidance. 2) Discuss current equipment and technique for performing stereotactic, sonographic, and MR imaging-guided breast needle biopsy. 3) Determine appropriate follow-up for breast lesions that undergo percutaneous biopsy. Disclosure: (C.H.L. is a research consultant to Ethicon Endo-surgery, Cincinnati, OH.)